human aldose reductase apoenzyme

coordinates from Bohren et al, 2005; PDB ID: 1XGD rendered with Cn3D

Kurt M. Bohren, PhD MS MEd

CSO, Owner
Dr. Bohren received his PhD in biochemistry from the University of Berne (Switzerland) in 1986. He was invited to do a postdoctoral training in molecular biology at the Baylor College of Medicine in Houston, Texas. He subsequently established the existence of the aldo-keto reductase superfamily in 1989 with a JBC paper that has been cited over 350 times. In 1992 he successfully crystallized recombinant human aldose reductase, competing with NASA (National Aeronautics and Space Administration), which was unable to obtain high-quality crystal of this protein in space during a Columbia shuttle mission in the same year. KurtThe β8α8 structure of aldose reductase, an enzyme thought to be involved in diabetic complications, established a new NADPH-binding motif for oxidoreductases, and was the first structure ever solved for the aldo-keto reductase superfamily. For this work Dr Bohren received a Career Development Award from the Juvenile Diabetes Foundation International. Fruitful collaborations with academic and industrial scientists led to many more highly-cited papers (over 2400 citations). Positions in academia and industry shaped Dr. Bohren‘s multiple areas of expertise such as metabolomics, mechanistic enzymology, protein engineering (proteomics) and production, assay development, gene regulation, diabetes, bone and cartilage diseases (osteoporosis, osteoarthritis, rheumatoid arthritis), and teaching.

David Owerbach, PhD MEd

Director of Project Management
Dr. Owerbach received his Ph.D. in biology from the State University of New York in Buffalo in 1978. He subsequently did post-doctoral training at the University of California at San Francisco from 1978-1980 where he was the first to map the human insulin gene to chromosome 11. From 1980-1984 he was a senior staff scientist at the Hagedorn Research Lab in Copenhagen, Denmark where he pioneered molecular genetic studies of type I diabetes. From 1984-1987 he continued these studies at the University of Massachusettes Medical Center in Worcester, MA as an AssisDavidtant Professor of Biochemistry. Here he received a Career Development Award from the Juvenile Diabetes Foundation International and a FIRST Award from the NIH. From 1987-2009, he was an Associate Professor of Pediatrics at Baylor College of Medicine in Houston, TX, where he performed seminal molecular genetic studies in families with diseases such as type I diabetes, congenital adrenal hyperplasia and rheumatoid arthritis. He received advanced training in statistics at the University of Houston in 2007 as part of a master’s degree program in Education. Dr. Owerbach has co-authored 60 peer reviewed scientific publications and received multiple research grants and is a recognized leader in the field of molecular genetics of type I diabetes

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